Opinion
Split ViewerImmunomodulatory and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease (IBD)
1Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
2Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
3Pediatric Respiratory Diseases Education and Research Network (PRDERN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
5Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran6 Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
6Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
7Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
8Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
9Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
10Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
11Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
12School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence to: *
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
J Pharmacopuncture 2018; 21(4): 294-295
Published December 31, 2018 https://doi.org/10.3831/KPI.2018.21.033
Copyright © The Korean Pharmacopuncture Institute.
Keywords
References
- Hodson R. Inflammatory bowel disease. Nature 2016;540:S97-S97.
- Ananthakrishnan AN. Nutritional Management of Inflammatory Bowel Diseases, 2016.
- Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn’s disease. Nature Genetics 2008;40:955-962.
- Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nature Reviews Immunology 2008;8:458-466.
- Hedayat M, Netea MG, Rezaei N. Targeting of Toll-like receptors: a decade of progress in combating infectious diseases. The Lancet infectious diseases 2011;11:702-712.
- Abraham C, Cho J. Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflammatory bowel diseases 2009;15:1090-1100.
- Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 2013;13:321-335.
- González-Sarrías A, Espín JC, Tomás-Barberán FA, García-Conesa MT. Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. Molecular nutrition & food research 2009;53:686-698.
- Veiga P, Gallini CA, Beal C, Michaud M, Delaney ML, DuBois A, et al. Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proceedings of the National Academy of Sciences 2010;107:18132-18137.
- Yang F, Oz HS, Barve S, De Villiers WJ, McClain CJ, Varilek GW. The green tea polyphenol (−)-epigallocatechin-3-gallate blocks nuclear factor-κB activation by inhibiting IκB kinase activity in the intestinal epithelial cell line IEC-6. Molecular Pharmacology 2001;60:528-533.
- Rosillo MA, Sánchez-Hidalgo M, Cárdeno A, Aparicio-Soto M, Sánchez-Fidalgo S, Villegas I, et al. Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats. Pharmacological Research 2012;66:235-242.
- Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Digestive diseases and sciences 2005;50:2191-2193.
- Vezza T, Rodríguez-Nogales A, Algieri F, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. Flavonoids in inflammatory bowel disease: a review. Nutrients 2016;8:211.
- Dodda D, Chhajed R, Mishra J. Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations. Pharmacological Reports 2014;66:169-173.
- Marchi P, Paiotti APR, Neto RA, Oshima CTF, Ribeiro DA. Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2, 4, 6-trinitrobenzene sulfonic acid-induced-colitis. Environmental toxicology and pharmacology 2014;37:819-827.
- Medda R, Lyros O, Schmidt JL, Jovanovic N, Nie L, Link BJ, et al. Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells. Microvascular research 2015;97:167-180.
Related articles in JoP
Article
Opinion
J Pharmacopuncture 2018; 21(4): 294-295
Published online December 31, 2018 https://doi.org/10.3831/KPI.2018.21.033
Copyright © The Korean Pharmacopuncture Institute.
Immunomodulatory and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease (IBD)
Hamid Reza Sodagari1, Zahra Aryan2,3,4, Amir Hossein Abdolghaffari5,6,7,8,*, Nima Rezaei4,9,*, and Amirhossein Sahebkar10,11,12
1Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
2Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
3Pediatric Respiratory Diseases Education and Research Network (PRDERN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
5Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran6 Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
6Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
7Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
8Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
9Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
10Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
11Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
12School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence to:*
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
- Hodson R. Inflammatory bowel disease. Nature 2016;540:S97-S97.
- Ananthakrishnan AN. Nutritional Management of Inflammatory Bowel Diseases, 2016.
- Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn’s disease. Nature Genetics 2008;40:955-962.
- Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nature Reviews Immunology 2008;8:458-466.
- Hedayat M, Netea MG, Rezaei N. Targeting of Toll-like receptors: a decade of progress in combating infectious diseases. The Lancet infectious diseases 2011;11:702-712.
- Abraham C, Cho J. Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflammatory bowel diseases 2009;15:1090-1100.
- Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 2013;13:321-335.
- González-Sarrías A, Espín JC, Tomás-Barberán FA, García-Conesa MT. Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. Molecular nutrition & food research 2009;53:686-698.
- Veiga P, Gallini CA, Beal C, Michaud M, Delaney ML, DuBois A, et al. Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proceedings of the National Academy of Sciences 2010;107:18132-18137.
- Yang F, Oz HS, Barve S, De Villiers WJ, McClain CJ, Varilek GW. The green tea polyphenol (−)-epigallocatechin-3-gallate blocks nuclear factor-κB activation by inhibiting IκB kinase activity in the intestinal epithelial cell line IEC-6. Molecular Pharmacology 2001;60:528-533.
- Rosillo MA, Sánchez-Hidalgo M, Cárdeno A, Aparicio-Soto M, Sánchez-Fidalgo S, Villegas I, et al. Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats. Pharmacological Research 2012;66:235-242.
- Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Digestive diseases and sciences 2005;50:2191-2193.
- Vezza T, Rodríguez-Nogales A, Algieri F, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. Flavonoids in inflammatory bowel disease: a review. Nutrients 2016;8:211.
- Dodda D, Chhajed R, Mishra J. Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations. Pharmacological Reports 2014;66:169-173.
- Marchi P, Paiotti APR, Neto RA, Oshima CTF, Ribeiro DA. Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2, 4, 6-trinitrobenzene sulfonic acid-induced-colitis. Environmental toxicology and pharmacology 2014;37:819-827.
- Medda R, Lyros O, Schmidt JL, Jovanovic N, Nie L, Link BJ, et al. Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells. Microvascular research 2015;97:167-180.