Austrian dermatologist Moriz Kaposi gave the first description of KVE as a complication of infant eczema, which is characterized by widespread chickenpox-like vesicles superimposed on an underlying skin condition . In 1941, Seidenberg suggested that the HSV was the primary cause of this disease . The diagnosis of KVE is mainly clinical, but can often be delayed because KVE is easily mistaken for an aggravated skin condition of an existing disease.
KVE is clinically characterized by the sudden appearance of monomorphic, umbilicated, grouped vesiculopustular lesions on the face, particularly around the eyes, neck, axillae, chest and upper extremities. The eruption is usually accompanied by fever and regional lymphadenopathy. Generally, the localized type of KVE heals naturally without permanent scarring; however, the systemic type of KVE can be fatal.
An impaired barrier function of the epidermis and an immunological abnormality have been proposed as causes for the development of the infection . Especially, the suppressed function of T cells causes AD patients to become vulnerable to viruses , as increased IL-4 secreting cells in the lesion interrupt the immune reaction to HSV by inhibiting Th-1 cell activity . Furthermore, KVE has been thought to occur due to decreased levels of IL-18, which is known to have profound influences on the pathological conditions of immune diseases . Skin lesions of AD are often damaged by scratching and can spread to their surroundings because HSV is commonly found even on unaffected regions, such as both hands . However, KVE does not always follow a preceding eczematous skin disease , and sometimes refers to an extensive infection of HSV in patients with decreased immunity. Taken altogether, the exact pathogenesis of KVE remains to be elucidated.
Tacrolimus, an immunosuppressant widely used for treating AD, is known to cause disruptions in the topical skin immune system, finally leading to secondary infections . Also, Stroud  reported that large amounts of steroids proportionately increased the severity scale of HSV.
Kim et al.  reported that 66.7% of AD patients were reluctant to use steroids because of their well-known side effects. Chin et al.  investigated the frequency of undergoing alternative treatments among AD patients and concluded that 84% had experienced alternative medicine and, 73.8% had taken herbal medications. The coexistence of Eastern and Western medicines in Korea is assumed to have provided more opportunity for choosing KM as a primary alternative.
The authors mixed HP and 25% BVP solutions as a main intervention in this case. The antiviral effect of mellitin, a main component of BVP, has been suggested in several research reports [18, 19], to play a key role in inhibiting viral activities, even those of HIV. To relieve the inflammatory responses caused by the virus, we selected HP, which is a typical antiphlogistics in KM. Various articles [20, 21] have reported on its proven anti-inflammatory effects and mechanisms. Selected acupoints, both BL13, are relevant to the lung, which governs the skin system.
The herbal medicine, Seungmagalgeuntang is a formula in the classic work - Bangyakhappyeon written by Hwang Do-yeon, and was documented as mainly curing warm diseases or seasonal common colds. Smallpox (痘瘡), an infectious viral disease, is also treated based on this formula .
Sama Upper, Middle and Lower of Master Tung acupuncture is used to treat skin diseases  and ST44 eliminates heat sensation of the face .
KVE is an acute, life-threatening, exigent skin disease. This case is significant in that an acute skin infection was completely cured with KM alone. In conventional Western medicine, the localized type of KVE can be cured within 7 to 10 days, on average, if antiviral agents are properly administered [4 - 6]. That viral disease can be treated with complementary and alternative medicine (CAM) methods in the same amount of time is meaningful, and if CAM is combined with conventional medicine, better control of more severe viral diseases can be expected. However, this case is only one case of mixed therapies, so more case studies will be needed.